High volume up bar candlestick confirms hammer candlestick formation in the support zone.
Monitor support zone and 20 EMA potential resistance.
Wednesday, January 23, 2008
Global project to map DNA of 1,000 people
Any two people may be roughly 99% identical at the genetic level. But the small differences are what tantalize scientists, and now they plan to map the DNA of 1,000 people worldwide to examine human genetic variation.
The goal: To create a catalog of these differences, the most detailed yet, that scientists would mine for variations that help explain why some people get certain illnesses and others don't.
MAPPING HUMAN TRAITS: Details about the 1000 Genomes project
The international project was announced Tuesday. It will be a collaboration of the Wellcome Trust Sanger Institute in Britain, the U.S. National Institutes of Health and China's Beijing Genomics Institute Shenzhen.
The Human Genome Project offered the first map of the approximately 25,000 human genes in 2003. It was based on a mix of DNA from different people. Only a handful of individual people's DNA has been mapped since.
http://www.usatoday.com/news/washington/2008-01-22-genomes_N.htm?csp=34
LabCorp(R) Announces the Availability of Affymetrix-Based Whole Genome Microarrays
Laboratory Corporation of America(R) Holdings (LabCorp(R)) (NYSE: LH) is pleased to announce the availability of an ultra high-density microarray, Affymetrix based technology (Whole-Genome Sampling Analysis). The offering continues the numerous recent advances in LabCorp's clinical genetics laboratory diagnostics. In 2005, LabCorp first offered the comparative genomic hybridization (CGH) based microarray diagnostics which focused on mental retardation and developmental delay. This targeted testing underscored the need for higher density whole genome coverage.
The Affymetrix-based technology provides analysis of DNA copy number changes - identifying deletions, gene amplifications and loss of heterozygosity (LOH).
"This new testing will offer unparalleled resolution for the detection of the etiology of mental retardation, developmental delay, autism and other clinically significant changes and underscores LabCorp's commitment to providing physicians and patients the highest quality services to meet their clinical needs," said Myla Lai-Goldman, M.D., Executive Vice President, Chief Scientific Officer and Medical Director of LabCorp.
About LabCorp(R) Laboratory Corporation of America(R) Holdings, a S&P 500 company, is a pioneer in commercializing new diagnostic technologies and the first in its industry to embrace genomic testing. With annual revenues of $3.6 billion in 2006, over 25,000 employees nationwide, and more than 220,000 clients, LabCorp offers clinical assays ranging from routine blood analyses to HIV and genomic testing.
http://www.cnbc.com/id/22779224/
DNA-Based Artificial Nose
Single-stranded DNA can be used to identify explosives and other airborne compounds.
Scientists have found a way to quickly identify which DNA sequences are ideal for detecting a particular odor and turn dried DNA into odor detectors. While many researchers are working on an electronic nose to detect toxins and explosives, this new platform could be used to create a wide array of sensors using existing high-throughput molecular-biology equipment.
"Now what we can do is take a microarray of 20,000 sensors ... and pick out those sensors that best respond to the odors of interest," says lead researcher Joel White of Cogniscent, a company based in North Grafton, MA, that manufactures odor-detection devices.
Compared with man-made sensor technologies developed for vision and hearing, our ability to mimic the chemical senses--smell and taste--is relatively primitive. To detect explosive materials such as TNT, scientists typically design highly specific polymers that fluoresce when they come in contact with their target compounds. But building a more generalized electronic nose platform that could detect a wider range of chemicals hasn't been possible.
Over the past decade, White and neuroscientist John Kauer of Tufts University have been working to improve their patented electronic nose, a handheld device that contains an array of 16 sensor types made of synthetic polymers. These polymers are cross-reactive, so that several sensor types may change shape in response to a single odor--a design analogous to the human nose. The polymers are dyed with a fluorescent marker, and their activation patterns can be monitored via optical electronic sensors and analyzed by an embedded microprocessor. But after 10 years of hard work, the pair had only been able to incorporate about 50 synthetic polymers--far less than the estimated 1,000 sensors in a human nose, which can respond to some 10,000 different odors.
Several years ago, the duo decided to test DNA--a natural polymer that is ubiquitous in the biological laboratories where the scientists spend most of their time. "When we first started talking about it with people, nobody imagined that dye-labeled DNA dried onto a substrate would respond to odors," says White.
The scientists began their experiments haphazardly: by scavenging short pieces of single- and double-stranded DNA from neighboring labs at Tufts and looking at their responses to several standard compounds. Their first experiments with dye-labeled double-stranded DNA gave them a hint that the approach could work, but all the sequences they tried responded to odors in the same way.
Single-stranded DNA, on the other hand, provided repeatable responses to odors, and this response depended on the specific sequence of four amino-acid types that make up the genetic code. With a typical sequence about 20 amino acids long, the team has the potential to create millions of sensor types. In the current issue of PLoS Biology, the researchers describe the response of just 30 sequences, but White says that now they have identified hundreds of useful DNA sequences, including one that responds to the vapor signature of TNT-containing land mines--an unusual finding indicating the versatility of the technique.
Alan Gelperin at Philadelphia's Monell Chemical Senses Center hails the discovery as a major step. "The whole field has been hindered by a lack of diverse sensor technology," he says. "This is the first demonstration that [DNA] could be used in this way." Since first learning of the approach during a conference, Gelperin has collaborated with University of Pennsylvania physicist Charlie Johnson to take the concept one step further by incorporating an electronic readout made with carbon nanotube transistors.
For now, White says that his team has incorporated his DNA sensors alongside the synthetic polymers in targeted projects, including one device for detecting ammonia gas, which would be useful for warning emergency responders at toxic spills or for monitoring pollution from livestock operations. He says that there is even interest among vintners in developing a device that could help sniff out counterfeit wines. "This was news to me," White says, laughing.
http://www.technologyreview.com/Biotech/20095/
JES Hammer Candlestick Pattern
On a Japanese Candlestick chart, the hammer is known as a reversal candlestick. Hammer candlesticks occur when a security moves significantly lower after the open, but rebounds to close well above the intraday low. In a perfect hammer, this tail is twice the length of the body and the candlestick will have no upper shadow or wick. The smaller the body and the longer the tail, the more significant the hammer is as a bullish indicator. Hammers form at trend bottoms.
If this candlestick forms during an advance, it is called a Hanging Man.
Monitor for confirmation candlestick formation
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